本杰明·比克曼博士(Benjamin Bikman, PhD),杨百翰大学细胞生物学和生理学副教授本,代谢健康和胰岛素抵抗领域最重要的科学家之一。
比克曼博士拥有生物能量学博士学位,并在新加坡国立大学和杜克大学代谢病研究所完成博士后研究。他目前正在探索胰岛素和酮类作为代谢功能关键驱动因素的对比作用。比克曼经常在同行评议的期刊上发表他的研究成果,在科学会议上发表演讲,并凭借其在胰岛素抵抗和代谢紊乱方面的专业知识被国际公认为领先科学家。
作为百翰大学生理学和发育生物学系的教授和研究员,比克曼博士大部分时间都在履行自己的职责。然而,他的热情和精力驱使他超越了科学,转而开发工具和资源,通过胰岛素控制来帮助改变世界的健康状况。
比克曼博士在他的新书《为什么我们生病》中记录了(1)胰岛素抵抗的上升及其在当今许多“繁荣瘟疫”中的作用,以及(2)如何反击。
《为什么我们会生病》
以下信息来自美国杨百翰大学生命科学院:https://lifesciences.byu.edu/
本杰明·比克曼博士实验室 (Dr. Benjamin Bikman Lab)
个人经历
比克曼博士的研究重点是阐明导致和伴随代谢紊乱的分子机制,如肥胖、2型糖尿病和痴呆症。延续他的学术背景(博士领域是生物能量学和博士后研究是代谢紊乱),他目前正在探索对比作用的胰岛素和酮作为代谢功能的关键驱动力。他经常在同行评议的期刊上发表他的研究成果,并在国际科学会议上发表演讲。
研究方向
我的实验室(肥胖与代谢实验室)的重点有两个。首先,我们的目标是确定解释伴随体重增加的疾病风险增加的分子机制,特别强调胰岛素抵抗和线粒体功能破坏的病因。其次,我们希望揭示负责脂肪形成和累积的新的细胞过程,特别强调白色/棕色脂肪以及胰岛素和酮的对比效应。
我们最近的大部分工作集中在胰岛素激素的致病性上。胰岛素虽然是健康生活所必需的,但在慢性升高时,会引起组织代谢功能的显著和有害变化。这项工作产生了几个项目,包括关注饮食中大量营养素(如碳水化合物和脂肪)对胰岛素稳态的不同影响,胰岛素对棕色脂肪组织(和代谢率)的影响,以及胰岛素诱导的大脑改变。
我们使用许多药理学和遗传学工具来更好地理解神经酰胺积累对与代谢功能相关的各种因素的起源和后果,包括信号转导、底物利用和能量消耗。
教育背景
- 东卡罗来纳大学生物能学哲学博士(2008年)
- 杨百翰大学运动生理学理学硕士(2005年)
- 杨百翰大学运动科学理学士(2003年)
成员资格
- 美国病理学研究学会(2017年至今)
- 线粒体生理学学会(2012年至今)
- 肥胖协会(2012年至今)
- 美国糖尿病协会(2011年至今)
- 美国生理学会(2010年至今)
职业资格
- 《国际分子科学杂志》主编、副主编(2018年至今)
- 其他,杨百翰大学糖尿病研究实验室(2016年至今)
- 美国生理学会-综合生理学委员会/理事会成员(2015年至今)
- 美国生理学会-转化生理学委员会/理事会成员(2015年至今)
- 编辑、副编辑、客座编辑(2016-2017)
Benjamin Bikman
Associate ProfessorCurriculum VitaeCell Biology and Physiology.Website: https://cell.byu.edu/bikman-labContact
3017 LSB
Provo, UT 84602
801-422-1798
Biography
Dr. Bikman’s research focus is to elucidate the molecular mechanisms that mediate the disruption that causes and accompanies metabolic disorders, such as obesity, type 2 diabetes, and dementia. Driven by his academic training (Ph.D. in Bioenergetics and postdoctoral fellowship with the Duke-National University of Singapore in metabolic disorders), he is currently exploring the contrasting roles of insulin and ketones as key drivers of metabolic function. He frequently publishes his research in peer-reviewed journals and presents at international science meetings.
Research Interests
The focus of my lab (the Laboratory of Obesity and Metabolism) is twofold. First, we aim to identify the molecular mechanisms that explain the increased risk of disease that accompanies weight gain, with particular emphasis on the etiology of insulin resistance and disrupted mitochondrial function. Second, we hope to reveal novel cellular processes that are responsible for fat development and accrual, with a particular emphasis on white/brown fat and the contrasting effects of insulin and ketones.
Much of our recent work is focused on the pathogenicity of the hormone insulin. Insulin, while necessary for healthy living, elicits significant and harmful changes in tissue metabolic function when chronically elevated. Several projects have stemmed from this work, including a focus on the varying effects of dietary macronutrients (e.g. carbohydrates vs. fats) on insulin homeostasis, the effects of insulin on brown adipose tissue (and metabolic rate), and insulin-induced brain alterations.
We employ numerous pharmacological and genetic tools to better understand the origins and consequences of ceramide accumulation on various factors related to metabolic function, including signal transduction, substrate utilization, and energy expenditure.
Education
- Doctor of Philosophy, Bioenergetics , East Carolina University (2008)
- Master of Science, Exercise Physiology , Brigham Young University (2005)
- Bachelor of Science, Exercise Science , Brigham Young University (2003)
Honors and Awards
- Travel Award, Oroboros Instruments (2012 – 2012)
- Travel Scholarship, Keystone Symposium (2011 – 2011)
- NIH: Pre-doctoral fellowship (2005 – 2006)
Memberships
- American Society for Investigative Pathology (2017 – Present)
- Mitochondrial Physiology Society (2012 – Present)
- The Obesity Society (2012 – Present)
- American Diabetes Association (2011 – Present)
- American Physiological Society (2010 – Present)
Professional Citizenship
- Editor, Associate Editor, International Journal of Molecular Sciences (2018 – Present)
- Other, BYU Diabetes Research Lab (2016 – Present)
- Committee/Council Member, American Physiological Society – Integrative Physiology (2015 – Present)
- Committee/Council Member, American Physiological Society – Translational Physiology (2015 – Present)
- Editor, Associate Editor, Guest Editor (2016 – 2017)
更多信息请访问杨百翰大学网站比克曼博士介绍。